Iglesia and Convento de Santa Clara was first a convent for postulates, but later became a church. The design of the building was very simple, until Don Rodrigo Pimentel modified the structure in 1648. Nuns, for several centuries, have had an intimate relationship with Iglesia and Convento de Santa Clara.

The Fortaleza Ozama (in Spanish; Ozama Fortress in English) is a sixteenth-century castle which lies at the entrance to Santo Domingo, Dominican Republic and overlooking the Ozama River. Named after this river, the castle, also referred to as "La Fortaleza" or "The Fortress", is the oldest formal military construction still standing in America. An impressive architectural structure of medieval style and design, the Tower of Homage (in Spanish: Torre del Homenaje) stands in the center of the grounds. The castle was designed to guard the entrance to the port of Santo Domingo, and defend the city from seaborne enemies. Construction began in 1502. It was well-built enough to serve as a prison until the 1960s, when the prison was closed, the "Fortaleza" was restored and it opened to the public as a tourist attraction. It is located at the end of Las Damas Street.

If you have little children than you should definitely visit The Children’s Museum, or in Spanish "Museo Infantil Trampolín". Several rooms are of interest inside the museum, including one with a big screen movie centered around the solar system. Also, kids can see what it's like to be in the middle of an earthquake, courtesy of the earthquake simulator.

This is the house of Don Rodrigo de Bastidas, governor of Santo Domingo. The building is not incredibly luxurious, as it looks more like a warehouse and is not necessarily convenient for living. The home was built to serve as a place where the Crown revenues and fortunes were kept before they were transfered to Spain. Upon entering the building, one will discover a big plaque of Santa Barbara from the 18th century. Art galleries are also located inside.

Construction on the governor's residence was completed around 1502. Former governor Nicolas Ovando personally designed it. The building has since been modified, yet was able to maintain its classic beauty. If you visit the home, make sure you venture out to the beautiful patio where you can witness the famous Ozama River.

Also known as National Mausoleum, Panteón Nacional was founded in 1714 and construction finished in 1748. The building has three different sections and was formerly a church. Panteón Nacional is especially popular for its ceiling mural in the main section, as well as for the 36 tombs of unknown Soldiers.

The chapel was built by Francisco Davila (also buried here), who had a lot of money. The chapel was a home for his relatives and the inside reflects that of a very rich owner. Outside, tourists will note a bell tower, created with stones.

Plaza España is a very beautiful plaza without any traffic, perfect for a stroll during the morning or afternoon. Along with the terrific shops, cafés, and restaurants, visitors may also be fortunate enough to catch a live show. Last but not least, the plaza is also famous for the Alcazar de Colon.