Kruger House is the historic Pretoria residence of the President of the South African Republic, Paul Kruger (1825-1904). It was built in 1884 by architect Tom Claridge and builder Charles Clark. Milk was used instead of water for mixing the cement from which the house was constructed, as the cement available was of poor quality. The house was one of the first in Pretoria to be lit by electricity. The house contains either the original furnishings or items from the same historical period, some of the many gifts that were presented to Kruger, and other memorabilia. An interesting feature of the house is the pair of stone lions on the veranda that were presented to President Kruger as a birthday gift in 1896 by the mining magnate Barney Barnato. The Kruger House is now a house museum that tries to recreate the ambience of the period in which Kruger lived.

The aim of the Police Service Museum is to tell about the history and functions of the South African Police with the help of historical items. The museum was officially opened in 1968 and is currently located in the Compol Building. The collections consist of documents, photos, records, newspapers, and magazines.

The National Cultural History Museum, also known as the "African Window," is located in the Old Mint. It is called the most dynamic museum in the city because of its constantly changing exhibitions. The museum houses a collection of at least five million objects related to the history and culture of South Africa, from the stone age to the present, and from both the indigenous peoples and European colonists.

The Transvaal Museum was founded in 1892 and today consists of four halls: the Hall of Life, which shows the history of life on Earth from its origins; the Mammal Hall, showing the evolutionary history of mammals and their ancestors; the Austin Roberts Bird Hall, with a display of 870 of southern Africa's birds; and GeoScience Museum, which exhibits a comprehensive collection of materials, precious and semi-precious stones.

The Science and Technology Museum of Pretoria is located in the Didacta building; it offers a great range of exhibits covering a variety of scientific disciplines, including physics, mechanics, biology, and space exploration. The museum also houses an inflatable planetarium, called the Starlab.

Melrose House is a stately Victorian mansion that was built in 1886 by the prosperous Pretoria businessman George Jesse Heys. It was named after the famous Melrose Abbey in Scotland. Melrose House gained fame during the Second Boer War (1899–1902), when Lord Roberts requisitioned it as the headquarters for the British forces after Pretoria was captured in June 1900. Today, this elegant house is a museum that represents the transition from Victorian to Edwardian architectural styles and interiors. The interior is characterized by colorful stained glass windows, paintings by English artists, carpets in rich colors, ornate ceilings and fireplaces, and valuable porcelain ornaments. The majority of these items were the property of the Heys family.