Iglesia Santa Bárbara is one of the most ancient churches, as it was built in 1537. The church features one main block with five additional branches. The inside is very beautiful, decorated with Gothic features and a ceiling ornamented with carved stones. Dominican hero Juan Pablo Duarte was baptized at Iglesia Santa Bárbara.

The chapel was built in 1502, although completely destroyed many years ago. Ermita de San Antón was than rebuilt to match the original appearance as close as possible. The religious building is small and old, yet more than worth your time in this very sacred establishment.

Monasterio de San Francisco in Santo Domingo de Guzman, Dominican Republic, is a monastery that was built around 1508, with the arrival of the Franciscan Fathers. The ruin is one of most important of the city. It is located in the Zona Colonial of Santo Domingo and was declared a "heritage Dominican". The Monastery of San Francisco, was one of the works of Nicolas de Ovando, which began its construction when it starts the arrival of the Franciscan fathers since 1508 and was the first monastery in the New World, and long after he was hit by a hurricane. According to historians, at the main entrance to the monastery, was buried Alonso de Ojeda, who later, his remains were moved to the former Convento Dominico October 12, 1942, at the same site where mesosulfuron found in 1892. Also found were the remains of Bartholomew Columbus. During the passage of Hurricane San Zenon in 1930, destroyed much of the building and installed 1940 was installed there procomio and Padre Billini madhouse.

Iglesia de San Miguel is a small temple from the 18th century, which was established from a thatched chapel built somewhere in the 16th century. The royal treasurer of the colony, Don Miguel de Pasamonte, ordered the construction of the church. Iglesia de San Miguel has undergone a couple of major reconstructions, however still maintains its original qualities.

Iglesia de las Mercedes was founded in 1549 and completed in 1555. Today, the church is one of the most well-known and most visited worship places in the city. Locals visit the church to worship the Virgen de Las Mercedes. The building is designed in Gothic style, and features a famous altar.

Iglesia and Hospital de San Lazaro was originally a venue for meditating, until it evolved into a hospital for people with low income. Jerónimo de Alcocer once supervised this hospital. In 1751, the hospital was destroyed by an earthquake but restored in 1880.

Iglesia and Convento Regina Angelorum, like a lot of the churches in the area, has undergone some restoration. It is a very attractive building, designed in Gothic style and decorated with 17th century pieces of ornament. Upon entering the temple, visitors will note the beautiful wall composed of silver.

The Capilla de la Tercera Orden Dominica was initially a section of the Iglesia y Convento de la Orden Dominica Entre la Capilla y la Iglesia in the 16th century. Originally constructed from wood and stones, the church now serves as offices for the minister.

The Cathedral of Santa Maria la Menor in Santo Domingo is the oldest cathedral in the Americas, begun in 1514 and completed in 1540. Fronted with a golden-tinted coral limestone façade, the church combines elements of both Gothic and Baroque with some lavish plateresque styles as exemplified by the high altar chiseled out of silver. The treasury has an excellent art collection of ancient woodcarvings, furnishings, funerary monuments, silver, and jewelry. Some historians believe that the remains which used to rest in the cathedral, before being removed to the Colombus Lighthouse, are those of famed navigator Christopher Columbus.

The chapel was built by Francisco Davila (also buried here), who had a lot of money. The chapel was a home for his relatives and the inside reflects that of a very rich owner. Outside, tourists will note a bell tower, created with stones.