The National Museum of Lithuania, established in 1952, is a state-sponsored historical museum that encompasses several significant structures and a wide collection of written materials and artifacts. It also organizes archeological digs in Lithuania. At its inception, the museum focused on the culture and history of the Lithuanian Grand Duchy. Made up mostly of Polish private collections, it was quite popular and received many visitors. The museum has five main departments: History and Latest History, Archaeology, Ethnography, Numismatics, and Iconography, containing a total of 800,000 items.

The Cathedral of Vilnius is the main Roman Catholic Cathedral of Lithuania. It is situated in Vilnius Old Town, just off of Cathedral Square. It is the heart of Lithuania's Catholic spiritual life. Inside, there are more than forty works of art dating from the 16th through 19th centuries; including frescoes and paintings of various sizes. During the restoration of the Cathedral, the altars of a presumed pagan temple and the original floor, laid during the reign of King Mindaugas, were uncovered. In addition, the remains of the cathedral built in 1387 were also located. A fresco dating from the end of the 14th century, the oldest known fresco in Lithuania, was found on the wall of one of the cathedral's underground chapels.

The Lithuanian Presidential Palace is situated in Old Town and is the official residence of the President of Lithuania. The palace dates from the 14th century. In 1997, the palace became the official seat of the President of Lithuania. This building contains empire and neoclassical architectural elements, which were very popular during 18th to 19th centuries.

The Amber Museum and Gallery offers an amber store on the ground floor and a museum in the basement. The exhibits of amber are spectacular. Visitors should utilize a magnifying glass to clearly see the exhibits. The gallery also features many pieces of jewelry made from amber.

St. Anne's Church is a Roman Catholic church in Vilnius' Old Town, on the right bank of the Vilnia River. It is a prominent example of both Flamboyant Gothic and Brick Gothic styles. St. Anne's is among the features of Vilnius Old Town that enabled the district to be included in the list of UNESCO World Heritage sites. A novel approach to bricks as a construction material was employed in the church's construction. The main façade, designed in the Flamboyant Gothic style, is its most striking feature. Traditional Gothic elements and shapes were used in unique ways; Gothic arches are framed by rectangular elements dominating a symmetrical and proportionate façade, creating an impression of dynamism. The church has one nave and two towers. It was built using 33 different kinds of clay bricks and painted in red. The interior is decorated in the Baroque style, as is its altar. The imitative neo-Gothic bell tower, constructed in the 1870s, stands nearby.

Bernardine Church is considered one of the biggest churches in the Lithuanian capital. It was built in 1469. The interior of the church is richly decorated and never fails to impress visitors. The church is definitely worth a visit.