Galleria degli Uffizi (Uffizi Gallery), Florence (must see)

If you could only visit one Renaissance landmark in Florence—or even the entire world—the Uffizi Gallery would be the top contender. Originally designed as government offices for the magistrates of Florence, this grand building was commissioned in the 16th century by Cosimo de’ Medici and brought to life by Giorgio Vasari. Though built for administrative purposes, the palace quickly evolved into the perfect setting for the Medici family’s extraordinary art collection. By 1765, the gallery opened its doors to the public and has since become one of Florence’s most visited museums.

Here, you’ll come face-to-face with some of the most iconic works in art history. Highlights include Sandro Botticelli’s “Birth of Venus” and “Adoration of the Magi”, as well as masterpieces by Leonardo da Vinci, Michelangelo, and Caravaggio. One of Michelangelo’s works displayed is “Doni Tondo”—a circular painting nearly four feet across that depicts the Holy Family. Created in 1504, it gives us an early glimpse of the vibrant palette the artist would later use in his frescoes on the Sistine Chapel ceiling.

While paintings and sculptures are the main attraction, don’t overlook the gallery’s interior design. The ceilings are intricately decorated, and each room carries its own sense of grandeur. With more than 50 opulent rooms to wander through, it’s easy to feel overwhelmed. That’s why a break at the rooftop café is a smart move. Grab a coffee, rest your feet, and soak in the stunning views of Florence that you won’t find anywhere else.

Because of its global fame, the Uffizi is rarely quiet. Expect long lines, especially during high season. Booking your ticket in advance through the official website is highly recommended—it will save you time, and you might even catch a discount. And one last note before you go: no liquids are allowed inside, so plan accordingly.